Cooperative omega loops in cytochrome c: role in folding and function.
نویسندگان
چکیده
Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.
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عنوان ژورنال:
- Journal of molecular biology
دوره 331 1 شماره
صفحات -
تاریخ انتشار 2003